激光微细加工技术在医疗器材领域的应用

杜帅,张成林,孙文明,等. 激光微细加工技术在医疗器材领域的应用[J]. 光电工程,2023,50(3): 220306. doi: 10.12086/oee.2023.220306
引用本文: 杜帅,张成林,孙文明,等. 激光微细加工技术在医疗器材领域的应用[J]. 光电工程,2023,50(3): 220306. doi: 10.12086/oee.2023.220306
Du S, Zhang C L, Sun W M, et al. Application of laser microfabrication in medical equipment[J]. Opto-Electron Eng, 2023, 50(3): 220306. doi: 10.12086/oee.2023.220306
Citation: Du S, Zhang C L, Sun W M, et al. Application of laser microfabrication in medical equipment[J]. Opto-Electron Eng, 2023, 50(3): 220306. doi: 10.12086/oee.2023.220306

激光微细加工技术在医疗器材领域的应用

  • 基金项目:
    安徽省自然科学基金面上项目 (1908085ME130);安徽省高校自然科学基金重点项目 (KJ2019A0791);安徽省2021年制造业重点领域产学研用补短板产品和关键共性技术攻关任务 (JB21096)
详细信息
    作者简介:
    *通讯作者: 姚燕生,y.ys@163.com
  • 中图分类号: TN249

Application of laser microfabrication in medical equipment

  • Fund Project: Anhui Natural Science Foundation - General Program (1908085ME130), Key Programs of Natural Science Foundation of Anhui University (KJ2019A0791), and Anhui Province's Key Areas of Manufacturing Industry in 2021: Production, Research and Research of Complementary Products and Key Common Technologies (JB21096)
More Information
  • 激光微细加工技术具有超快、超精密等特性,在医疗器材领域的应用中有着传统加工技术无可比拟的独特优势,尤其是对生物材料表面加工改性,提高材料生物相容性方面有着不可替代的作用。本文综述了近年来激光微加工技术在医疗器材制造加工领域的最新应用,着重介绍了血管支架和骨支架的结构与表面制造,生物材料表面改性与抗菌性处理等。最后对目前激光微加工技术存在的局限性做了讨论,对未来激光微加工技术在医疗器材领域的应用发展做了展望。

  • Overview: In recent years, the manufacturing industry has been developing in the direction of precision and high precision. In order to improve machining accuracy, scholars at home and abroad have carried out a lot of research on micro-machining. As a high-precision, green, and environment-friendly non-contact processing technology, laser processing has good flexibility and controllability. Because of its high accuracy, fast speed, small damage, and high power density, it has a broad application prospect in the biomedical field. Laser micro-processing technology endows biomaterials with new structures and functions, fully mobilizes the human body's self-repair ability, and realizes the permanent rehabilitation of damaged tissues or organs, which has become the development direction of contemporary biomedical science.

    In order to systematically demonstrate the achievements of laser micromachining technology in the field of biomedicine, this paper analyzes the advantages of laser micromachining in the precision forming and surface modification of medical components from the manufacturing process and surface microstructure of medical devices, and summarizes the latest progress of laser micromachining technology in the manufacturing and processing of typical biomedical components. The influence of surface microstructures on the biocompatibility and antibacterial properties of medical components was explored. Furthermore, the achievements of laser micro-processing technology in the field of medical equipment manufacturing were systematically demonstrated.

    Finally, the limitations of laser processing at present are summarized, and the application and development of laser micromachining technology in the field of medical equipment in the future are prospected. Although laser micro-processing technology can micro-process a new generation of implantable medical devices with extremely fine structure, making the commercial use of the next generation of implantable medical devices feasible, the development of laser micro-processing technology in the biomedical field is not mature enough, the production efficiency is low, and the work stability needs to be improved. For the laser micromachining process, a complete set of theories has not yet been formed to explain the physical nature of the interaction between the laser and material under the extreme conditions of ultra-fast, ultra-short, and ultra-strong, nor can the impact of laser micromachining on the material structure and physical and chemical properties be well evaluated. The next work still needs a lot of basic and regular research. At the same time, according to the characteristics of laser micromachining and the properties of the processed materials, it is also necessary to develop simulation analysis software to simulate the micromachining process and optimize the parameters of the laser micromachining process.

  • 加载中
  • 图 1  SS316L不锈钢支架[10]

    Figure 1.  SS316L stainless steel stent[10]

    图 2  切割面SEM图像[15]。 (a) NiTi合金;(b) PtIr合金

    Figure 2.  SEM image of cutting face[15]. (a) NiTi alloy; (b) PtIr alloy

    图 3  316L不锈钢血管支架[16]。(a) 实物图; (b) 局部放大图;(c) 储药孔结构

    Figure 3.  316L stainless steel vascular stent [16]. (a) Physical objects; (b) Amplification; (c) Drug storage hole

    图 4  飞秒激光切割PLLA[20]。 (a) 带微三角形槽口PLLA 薄片;(b) 局部结构

    Figure 4.  Femtosecond laser cutting PLLA[20]. (a) Sheet with triangular notch structures; (b) Local structure

    图 5  聚乳酸(PLA)激光加工[21]。 (a) 支架结构;(b) 574倍显微图

    Figure 5.  Laser processing of PLA[21]. (a) Structure of PLA scaffold; (b) 574x micrograph

    图 6  激光3D打印的骨科植入物。 (a) 人工关节;(b) 头额骨;(c) 椎间融合器

    Figure 6.  Orthopaedic Implants by the laser 3D printer. (a) Artificial joint; (b) Forehead bone; (c) Intervertebral fusion cage

    图 7  生物陶瓷支架激光制造[36] 。 (a) 激光沿着预定路径选择性地烧结β-TCP粉末;(b) 多孔β-TCP生物陶瓷支架的宏观形态;(c) 单个烧结路径的微观结构

    Figure 7.  Laser manufacturing of bioceramic stent[36]. (a) Selective laser sintering along a predetermined path β-TCP powder; (b) Porous β-Macro morphology of TCP bioceramic stent; (c) Microstructure of a single sintering path

    图 8  DLP制造HA生物陶瓷支架的照片[37]。(a) 总体结构;(b) 放大照片

    Figure 8.  Photo of HA bioceramic stent manufactured by DLP[37]. (a) Structure; (b) Enlarged photo

    图 9  PPy基主动导管[44]

    Figure 9.  PPy-based active catheter[44]

    图 10  3D光纤材料结构[46]。 (a) 通过激光处理处理的图像;(b) 结构微观图

    Figure 10.  3D optical fiber structure[46]. (a) Processed by laser processing; (b) Structural micrograph

    图 11  三种微纳结构[54]。 (a) 飞秒激光制造的微纳结构;(b) hMSCs在 3种表面的形状

    Figure 11.  Three kinds of micro/nano structures[54]. (a) Fabricated micro/nano structures; (b) The shape of hMSCs on the surface of three structures

    图 12  经激光加工和酸洗在TC4表面产生的微纳结构[55]

    Figure 12.  Micro nano structure produced on TC4 surface by laser processing and pickling[55]

    图 13  被飞秒激光扫描处理前(a)和后(b)钛表面与水珠表面接触角的对比[66]

    Figure 13.  Comparison of contact angle between titanium surface and water droplet surface before (a) and after (b) femtosecond laser scanning treatment[66]

    表 1  医疗器械领域中激光加工成形技术

    Table 1.  Laser processing and forming technology in the field of medical devices

    医疗器材激光类型加工材料
    血管支架飞秒激光,纳秒激光,皮秒激光,微秒激光金属材料,可降解聚合物材料
    骨支架激光3D打印金属材料,生物陶瓷等
    下载: 导出CSV

    表 2  血管支架激光加工材料及方法

    Table 2.  Materials and methods for laser processing of vascular stent

    支架材料激光加工方法激光波长/nm
    316L不锈钢Nd:YAG激光,微秒激光,纳秒激光,飞秒激光355~1064
    钛及其合金飞秒激光1064
    镁合金飞秒激光-辅助气体1064
    高分子材料飞秒激光-辅助气体,飞秒激光-辅助衬套1030~1064
    下载: 导出CSV

    表 3  激光3D打印骨支架

    Table 3.  Laser 3D printing bone stent

    骨支架材料3D打印技术(微纳秒激光)
    金属材料(钛,镁,不锈钢等)SLM
    生物陶瓷SL, SLA, SLS, DLP
    下载: 导出CSV
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收稿日期:  2022-11-21
修回日期:  2023-02-14
录用日期:  2023-02-14
网络出版日期:  2023-03-16
刊出日期:  2023-03-25

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